Sermorelin injections are a prescription therapy in which a small dose of sermorelin, a lab-made copy of part of growth hormone-releasing hormone, is injected under the skin, usually at night before bed. It prompts your pituitary gland to release your own growth hormone rather than supplying growth hormone directly. A licensed provider decides whether it fits you and sets the dose and schedule.
If you are looking into sermorelin injections, you will find plenty of dosing charts and very little about how the therapy actually works from first visit to monthly refill. This guide walks through the whole path: what sermorelin is, why it is given as a nightly subcutaneous injection, what your provider decides, what arrives at your door, how follow-up works and what it costs at telos rx.
What sermorelin injections are
Sermorelin, also called GRF 1-29, is a synthetic peptide matching the first 29 amino acids of growth hormone-releasing hormone (GHRH). A 1999 review in BioDrugs describes it as the shortest synthetic peptide with the full biological activity of GHRH, and notes that it specifically stimulates growth hormone secretion from the anterior pituitary.
That last part matters. Sermorelin is not HGH. It does not add growth hormone to your body. It signals the pituitary to release its own, in pulses, and that release stays subject to the body's normal brakes, including somatostatin and feedback from IGF-1. The difference is unpacked in sermorelin vs HGH.
Sermorelin was once sold as an FDA-approved product called Geref (sermorelin acetate). The manufacturer discontinued it, and in 2013 the FDA published a Federal Register determination that Geref was not withdrawn from sale for reasons of safety or effectiveness. Today, sermorelin is prescribed as a compounded medication. Compounded sermorelin is not FDA-approved. The salt form is explained in what is sermorelin acetate.
Why sermorelin therapy is a nightly injection
Two practical reasons shape how sermorelin is given.
Timing. In adults, the most reproducible growth hormone pulse happens shortly after you fall asleep, during the first period of deep, slow-wave sleep. A review of growth hormone secretion during sleep explains that this sleep-related release appears to depend mainly on GHRH. A bedtime dose is timed to sit alongside that natural pulse.
Route. Sermorelin is a peptide, so it is given by injection rather than swallowed. Subcutaneous means into the fat just under the skin, using a small needle, which makes it practical at home. Once-daily subcutaneous dosing at bedtime is also how sermorelin was studied in children with growth hormone deficiency, as summarised in the BioDrugs review.
telos rx prescribes compounded sermorelin only as a small nightly subcutaneous injection. It does not offer a nasal spray, oral or tablet form. If you have seen those elsewhere, sermorelin nasal spray explained and sermorelin pills vs injections cover why.
Sermorelin injection therapy, start to finish
Here is what the full path looks like when you start sermorelin injections online with telos rx.
- Complete a short online visit. You share your health history, current medications, goals and any recent lab work.
- A licensed provider reviews it asynchronously. There is no scheduled appointment. Every prescription is subject to medical approval by a licensed provider, and you pay $0 if you are not approved.
- Your provider builds the plan. If sermorelin is appropriate, they decide the dose, the schedule and what monitoring you need.
- A licensed US partner pharmacy fills it. Your prescription ships free with 2-day delivery in discreet packaging.
- You start a simple nightly routine. You follow the pharmacy label and your provider's instructions for preparing and giving each injection.
- Ongoing follow-up. You message your care team with questions, report side effects, and your provider reviews how things are going and adjusts the plan if needed.
Wondering whether sermorelin injections suit you? Start a short online visit. A licensed provider reviews it, and you pay nothing if you are not approved.
See if sermorelin is right for youWhat your provider decides
Most of the important choices in sermorelin therapy sit with the prescribing provider, not with you and not with a chart online.
| Decision | What it is based on | Where you see it |
|---|---|---|
| Whether sermorelin is appropriate | Health history, medications, goals, contraindications | Your provider's review |
| Sermorelin dose | Your history, how you respond, side effects | Your prescription and pharmacy label |
| Schedule and timing | The prescription and your daily routine | Your provider's instructions |
| Monitoring | Your baseline health and response over time | Lab orders and check-ins |
| Changes or stopping | Response, side effects, labs, your goals | Follow-up with your care team |
How much sermorelin per day?
This is one of the most searched sermorelin questions, and the honest answer is that your provider sets it. There is no single sermorelin dose to copy. Compounded preparations vary in concentration, so the same number of units on a syringe does not mean the same amount of medication across vials or pharmacies.
Your prescription and pharmacy label tell you exactly what was prescribed for you. If anything on the label is unclear, ask your care team before you inject. How providers think about this is covered in the sermorelin dosage guide.
What arrives in your shipment
Exact contents depend on the dispensing pharmacy and your prescription, but you can expect your sermorelin vial along with written instructions specific to it. Sermorelin is often supplied as a powder that is mixed with a sterile liquid before use, and the label explains how and when to do this for your vial.
The label also covers storage and how long a prepared vial can be used. Treat the label as the instruction to follow, not a video or a forum post. If you are unsure whether you have every supply you need, message your care team before your first dose.
How to take sermorelin: the nightly routine
Once the plan is set, the routine itself is short. People typically:
- Pick a consistent time close to bed, as directed by their provider
- Wash hands and clean the injection site before each dose
- Use a fresh needle every time and dispose of it in a sharps container
- Rotate between sites, commonly the abdomen or outer thigh, so one spot is not overused
- Note anything unusual and message the care team rather than changing the dose on their own
Step-by-step technique is in how sermorelin is administered, and site planning is in sermorelin injection site rotation.
Side effects and who should not take it
Reported side effects of sermorelin include:
- Redness, swelling or pain at the injection site
- Flushing
- Headache
- Nausea or dizziness
- Trouble sleeping
Long-term human safety data for compounded sermorelin are limited, and it is worth saying that plainly. Sermorelin is generally not appropriate during pregnancy or breastfeeding, with active cancer or a history of certain cancers, with untreated hypothyroidism, or with a known hypersensitivity to it. Your provider makes the final call. More detail is in sermorelin side effects and is sermorelin safe?
Monitoring and follow-up
Sermorelin therapy is not a one-time decision. Your provider may order labs, such as IGF-1, a marker of growth hormone activity, to see how your body is responding and to guide any changes. You can message your care team at any point between check-ins.
What monitoring usually involves is covered in sermorelin labs and monitoring. If you are thinking about the longer term, see what happens when you stop taking sermorelin.
Sermorelin is studied for its role in supporting the body's own growth hormone release. No particular result can be promised, and individual experiences vary.
What sermorelin injections cost at telos rx
Sermorelin at telos rx is as low as $125 per month. Plans are FSA/HSA eligible, shipping is free, and you can cancel anytime. telos rx is LegitScript-certified. You can see the details on the sermorelin page, and a wider look at pricing is in sermorelin cost.
Comparing sermorelin with testosterone therapy? Read sermorelin vs TRT. Weighing a local clinic against telehealth? See sermorelin near me vs online.
Frequently asked questions
What are sermorelin injections?
Sermorelin injections are a prescription therapy in which sermorelin, a synthetic copy of the first 29 amino acids of growth hormone-releasing hormone, is injected under the skin. It prompts the pituitary gland to release the body's own growth hormone. It is not HGH.
Why is sermorelin injected at night?
In adults, the most reproducible growth hormone pulse occurs shortly after falling asleep, during deep sleep. A bedtime injection is timed to sit alongside that natural pulse. Your provider confirms the timing for your plan.
How much sermorelin per day should I take?
Your provider sets your sermorelin dose based on your health history and how you respond, and your pharmacy label states exactly what was prescribed. Compounded concentrations vary, so do not copy a dose from a chart or another person.
Is sermorelin FDA-approved?
No. Compounded sermorelin is not FDA-approved and has not been evaluated by the FDA for safety, effectiveness or quality. An earlier branded product, Geref, was FDA-approved before it was discontinued by its manufacturer.
What side effects can sermorelin injections cause?
Reported side effects include redness, swelling or pain at the injection site, flushing, headache, nausea, dizziness and trouble sleeping. Long-term human safety data for compounded sermorelin are limited, so report anything concerning to your provider.
How much do sermorelin injections cost at telos rx?
Sermorelin at telos rx is as low as $125 per month, FSA/HSA eligible, with free 2-day discreet shipping and the option to cancel anytime. You pay $0 if a licensed provider does not approve your prescription.
Ready to take the next step? Start your online visit. A licensed provider reviews it without a scheduled appointment and decides whether sermorelin injections are appropriate for you.
Start your online visitThis article is for general education and is not medical advice. Compounded sermorelin is not FDA-approved and has not been evaluated by the FDA for safety, effectiveness or quality. All prescriptions are subject to medical approval by a licensed provider; approval is not guaranteed. Individual experiences vary. telos rx is an online-first, asynchronous telehealth service and is LegitScript-certified. Medications are filled by licensed US partner pharmacies.