MOTS-c is a mitochondrial-derived peptide studied for metabolic and exercise physiology research. Patients can request a telehealth evaluation through the TelosRX Telehealth Portal to discuss compounded access.
What Is MOTS-c?
MOTS-c is a 16-amino-acid peptide encoded within mitochondrial DNA. It is studied in preclinical research for metabolic regulation pathways.
MOTS-c is not an FDA-approved drug. It is available through compounding pharmacies under valid prescription.
Common Discussion Points
Patients often raise MOTS-c during evaluations for:
- Mitochondrial function research interest
- Metabolic optimization discussions
- Insulin sensitivity research
- Exercise physiology applications
A licensed provider determines clinical appropriateness individually.
Regulatory Context After the July 2026 PCAC Meeting
In July 2026 the FDA's Pharmacy Compounding Advisory Committee voted to recommend adding MOTS-c to the list of substances that can be used in compounding, a non-binding step. On October 28, 2026, HHS announced a temporary enforcement discretion policy that covers single-ingredient subcutaneous or intramuscular MOTS-c compounded by state-licensed pharmacies with a valid prescription, under strict sourcing, testing and reporting conditions (Federal Register notice). It is not FDA approval, it applies only while FDA decides through rulemaking, and HHS can revisit it. Patients interested in compounded access should consult a licensed provider.
How TelosRX Handles MOTS-c
TelosRX is an online-first telehealth service. Patient evaluation is asynchronous, and compounded medications are prepared through our licensed pharmacy partner.
- Step 1: Complete an asynchronous telehealth intake at TelosRX.
- Step 2: Licensed provider review.
- Step 3: Prescription issued if clinically appropriate.
- Step 4: Compounded MOTS-c ships discreetly to your door.
Important Compliance Information
MOTS-c is not FDA-approved. Compounded preparations are prepared under federal compounding regulations.
Prescriptions require evaluation by a licensed healthcare provider. Approval is not guaranteed. Individual results vary.
TelosRX operates under LegitScript-certified telehealth standards.
Start your private evaluation at TelosRX.