Tirzepatide vs Semaglutide
Compare effectiveness, side effects, and pricing — then find the custom formula that fits your goals. Both are prescribed only when appropriate, subject to medical approval by a licensed provider.
How they compare
| Feature | Tirzepatide | Semaglutide |
|---|---|---|
| Drug class | Dual GIP + GLP-1 receptor agonist | GLP-1 receptor agonist |
| How it works | Targets two gut-hormone pathways to curb appetite | Targets one GLP-1 pathway to curb appetite |
| Effectiveness | Dual action; associated with greater average weight reduction in clinical trials | Well-studied, with significant weight reduction in clinical trials |
| Formats at TelosRX | Injection, needle-free sublingual, microdosed | Injection |
| Dosing | Weekly, titrated up gradually | Weekly, titrated up gradually |
| Common side effects | Nausea, digestive changes, usually early on | Nausea, digestive changes, usually early on |
| Starts from | $99/mo (12-month plan) | $49/mo (12-month plan) |
| Best for | Wanting the dual-pathway, maximum-strength option | Wanting a proven, lower-cost place to start |
Compounded tirzepatide and semaglutide are not FDA-approved. They are prepared by licensed US pharmacies and prescribed only when appropriate. For background, see the NIH overview of weight-management medications.
Which formula fits you?
- You want the dual-hormone (GIP + GLP-1) approach
- You're looking for the strongest option available
- You'd prefer needle-free sublingual or microdosed formats
- You want a proven, well-studied GLP-1
- You'd like the most affordable place to start, from $49/mo
- You prefer a single-pathway medication
Not sure which is right?
A US-licensed provider reviews your intake and recommends the formula that fits your health and goals — usually within hours, fully online. No appointment needed.
Start your intake →TelosRX is LegitScript-certified. Compounded medications are not FDA-approved and are prepared under federal compounding regulations. Approval is subject to evaluation by a licensed provider; approval is not guaranteed. Individual results vary. TelosRX operates as an online-first, asynchronous telehealth service.